Case reports Table Cases offamilial translocations with aneuploidy not involving translocated chromosomes

relationship between the two chromosomal aberrations. To our knowledge, the present case is the first report of Turner's syndrome with a familial balanced translocation not involving the X chromosome. Turner's syndrome occurs in about 1 in 6800 live births. Cases with balanced translocations occur in about 1 in 500 live births and most cases originate from familial translocation carriers (Bochkov et al., 1974; Hamerton et al., 1975; Nielsen and Sillesen, 1975). Hence, the expected likelihood of both abnormalities occurring in the same female should be about 1 in 3 400 000 live births through chance alone. From a similar calculation the expected occurrence of Down's syndrome, Klinefelter's syndrome, and 18 trisomy syndrome with a familial balanced translocation should be about 1 in 350 000,